绵羊抗人载脂蛋白(a)多克隆抗体  Sheep Anti-Human Apo (a), Affinity Pure

Host Species: Sheep

Concentration: 1 mg/ml (OD 1.35 / 280 nm)

Antigen: Human Apolipoprotein (a)

Purification: Affinity purified

Buffer: 75 mM Sodium Phosphate, 75 mM NaCl, 0.5 mM EDTA, 0.02% NaN3, pH 7.2

Specificity:Specifically binds to human Lp (a) and apo (a). No cross- reaction to Apo B-100/48; minor to plasminogen. Dilution for immunoblot and ELISA range: 1,000 to 80,000.

Use: The antibody can be used for detection of human albumin in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation.

Storage: -20°C for long-term storage, 4°C for short- term storage. Aliquot to avoid repeated freezing and thawing.

*These products are for research or manufacturing use only, not for use in human therapeutic or diagnostic applications.

脂蛋白(a)[Lp(a)]的结构与低密度脂蛋白(LDL)相似，涉及颗粒的大小和脂质组成以及载脂蛋白B-100(apo B-100)的存在。除了载脂蛋白B-100外，Lp(a)还有另一种蛋白，载脂蛋白(a)[apo (a)]，该糖蛋白的分子量在400至700 kDa之间变化很大（Maranhão et al.， 2013）。

以往的研究表明，载脂蛋白(a)与纤溶酶原具有相似的结构，含有一个丝氨酸蛋白酶结构域和两种类似纤溶酶原的kringle结构域(McLean et al., 1987) 。人脂蛋白[a]、Lp[a] 的血浆浓度与冠状动脉疾病高度相关（Gaubatz et al., 1990）。