Synonyms : Alpha-1-antichymotrypsin, ACT, Cell growth-inhibiting gene 24/25 protein, SERPINA3, AACT, A1ACT, GIG24, GIG25, MGC88254.
Introduction: Alpha 1 ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1- ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain.
Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.
Description: Human Alpha-1 AntiChymotrypsin produced from normal human serum having a molecular mass of 68kDa.
Source : Human Serum.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation : Lyophilized from 0.02M NH4HCO3.
Solubility : It is recommended to reconstitute the lyophilized human A1ACT in phosphate buffer pH > 7.0 containing 0.15M NaCl.
Stability : Human SERPINA3 although stable at room temperature for 3 weeks, should be stored between 2-8°C.
Purity: Greater than 99.0%.
Human Virus Test : Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.