首 页 关于中昊 新闻资讯 产品目录 资料下载 订购须知 人才招聘 代理品牌 联系我们
详细查找
 
Animal-Free Rat GDNF
AF-450-51-2 PeproTech
待定 / 2ug
推荐产品
热门产品
产品说明 / Product Overview:
别名: Glial-Derived Neurotrophic Factor, ATF-1
描述: GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional rat GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine knot configuration. The calculated molecular weight of Recombinant Rat GDNF is 30.0 kDa. Manufactured using all Animal-Free reagents.
氨基酸序列: MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCEAAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDSLV YHILRKHSAK RCGCI
来源: E.coli
纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性: Determined by its ability to stimulate the proliferation of rat C6 cells.
相关产品 / Related Products :
  • PeproGMP? Recombinant Human Flt3-Ligand
  • PeproGMP? Recombinant Human Flt3-Ligand
  • PeproGMP? Recombinant Human TPO
  • PeproGMP? Recombinant Human TPO
  • PeproGMP? Recombinant Human SCF
  • PeproGMP? Recombinant Human SCF
  • PeproGMP? Recombinant Human IL-6
  • PeproGMP? Recombinant Human IL-6
  •  
    版权所有:北京中昊新生科技有限责任公司 | 电话:010-59871930 59871931 统一服务热线:400-888-0207
    传真:010-59871932 邮箱:info@biopcr.com
    Copyright © 2009-2014 biopcr.com. All Rights Reserved. 京ICP备05075339号 京公网安备110108400889