首 页 关于中昊 新闻资讯 产品目录 资料下载 订购须知 人才招聘 代理品牌 联系我们
详细查找
 
Thioflavin T 硫代黄素T,超纯级
23060 AAT
1050.00 / 1g
推荐产品
热门产品
产品说明 / Product Overview:

Ex (nm): 412
Em (nm): 482
MW: 318.87
Solvent: DMSO
硫代黄素T(ThT),也称为碱性黄1或CI 49005,是一种苯并噻唑盐。这种染料用来使在阿尔茨海默患者大脑中发现的由β-淀粉状蛋白组成的斑点可视化。当它与β折叠结合时,例如淀粉状蛋白寡聚体上的,这种染料会产生特征性120nm红色的激发光谱转移,选择性的在450nm处被激发,产生的荧光信号在482nm处。硫代黄素T(ThT)能快速、特异性的与由β-淀粉状蛋白(1-40)构成的反向平行的β-折叠纤维结合,但是它不与单体或者寡聚体中间体结合。硫代黄素T(ThT)的这种结合不会干扰β-淀粉状蛋白多肽聚合形成淀粉状蛋白纤维。

Thioflavin T (ThT), also called Basic Yellow 1 or CI 49005, is a benzothiazole salt. The dye is used to visualize plaques composed of beta-amyloid found in the brains of Alzheimer's disease patients. When it binds to beta sheets, such as those in amyloid oligomers, the dye undergoes a characteristic 120 nm red shift of its excitation spectrum that may be selectively excited at 450 nm, resulting in a fluorescence signal at 482 nm. ThT binds rapidly and specifically to the anti-parallel beta-sheet fibrils formed from synthetic beta-amyloid (1-40), but does not bind to monomer or oligomeric intermediates. The binding of ThT does not interfere with the aggregation of beta-amyloid peptide into amyloid fibrils.
 

相关产品 / Related Products :
  • Thioflavin S 硫代黄素S,超纯级
  •  
    版权所有:北京中昊新生科技有限责任公司 | 电话:010-59871930 59871931 统一服务热线:400-888-0207
    传真:010-59871932 邮箱:info@biopcr.com
    Copyright © 2009-2017 biopcr.com. All Rights Reserved. 京ICP备17062316号 京公网安备11010802024962号