Annexin V Apoptosis Detection Kit-PEAnnexin V细胞凋亡检测试剂盒-PE
Annexin V Apoptosis Detection Kit-PEAnnexin V细胞凋亡检测试剂盒-PE是由北京中昊新生科技有限公司提供，德国ZellBio（ZELLX）是高质量生命科学研究材料的开发者和制造商，开发创新的生物测定和免疫测定试剂盒以及化学药品,产品包括：生物测定试剂盒，和高质量植物学研究试剂
Reactivity:Human;Sample type validated:Apoptosis is the process of programmed cell death, which occurs as a normal physiologic process and plays an important role in embryonic development and maintenance of tissue homeostasis. It is characterized by special morphologic features, including asymmetric loss of plasma membrane and attachment- as one of the earliest features, condensation of the nuclear chromatin, internucleosomal cleavage of DNA and cell membrane blebbing. During apoptosis, the membrane phospholipid phosphatidylserines (PS) are translocated from the inner to the outer layer of the plasma membrane and exposed to the external cellular environment.
Annexins are a family of calcium-dependent phospholipid-binding proteins that can bind to PS. Fluorophoe-conjugated Annexin V is commonly used to visualize apoptosis via detection of externalized phosphatidylserine residues on the outer layer of plasma membrane in apoptotic cells. Binding of Annexin V and PS occurs in the presence of Calcium ion (Ca2+). Upon the attachment of apoptotic cells to labelled Annexin V, apoptosis can be measured using fluorescent microscopy or flow-cytometry.