Murine Anti-Factor IX抗体

Clone GMA-121

描述:
Factor IX (FIX) is a vitamin K-dependent zymogen that plays an essential role in the coagulation cascade leading to thrombus formation. In the presence of calcium, activated Factor IX (FIXa) complexes with Factor VIIIa on phospholipid surfaces to create the tenase complex, which converts Factor X to its activated form. Defect or deficiencies in FIX lead to the X-linked recessive bleeding disorder hemophilia B. GMA-121 binds to FIX and detects the light chain of FIXa in both ELISA and Western blot format.

物种反应性: Human

来源: Murine

特异性: Light chain of FIX/FIXa

免疫原: Human Factor IX

同型: IgG1

应用
ELISA: Binds immobilized Human FIX/IXa.

Immunoblotting: Western blotting detects human FIX and Human FIXa light chain under reduced conditions.

Inhibition: Does not prolong plasma clot time in APTT clotting assay.

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