CD45抗体

描述:Goat polyclonal antibody to CD45. It is a 180-220 kDa type I transmembrane glycoprotein and a member of the protein tyrosine phosphatase (PTP) family. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. It is expressed in all hematopoietic cells, but highest on lymphocytes. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. It has intrinsic tyrosine phosphatase activity and it is essential for T and B cell antigen receptor-mediated activation. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signalling. CD45 also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signalling. The cross-linking of CD45 induces apoptosis in lymphocytes.

别名:B220, CD45 antigen, CD45R, GP180, L-CA, LCA, leukocyte common antigen, LY5, protein tyrosine phosphatase, PTPRC, receptor type c polypeptide, receptor-type tyrosine-protein phosphatase C, RP11-553K8.4, T200, T200 glycoprotein, T200 leukocyte common antigen antibody.

浓度: 3 mg/ml

抗体类型: 一抗.

Target Name: Anti-CD45

Accession Number: ENSG00000081237

宿主: Goat

免疫原物种: Human

免疫原类型: Recombinant protein

免疫原: Purified recombinant peptide derived from within residues 1,260 aa to the C-terminus of human CD45 produced in E. coli.

亚型: IgG

克隆: Polyclonal

已确认的反应种属: Human, mouse, rat, bovine, canine, chicken/avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep, simian, other

特异性: Using Jurkat cell lysate detects a band 180-220 kDa by Western blot.

储存缓冲液: PBS, 20% glycerol and 0.05% sodium azide

纯化: Epitope affinity purified

偶联物: Unconjugated

RRID: AB_2333126

经验证的应用: WB

推荐稀释: WB:1:500-1:2,000, IHC-P:1:250-1:1,000, IHC-F:1:250-1:1,000

储存条件: Store at -20 C for long-term storage. Store at 2-8 C for up to one month.



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