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SPDP Crosslinker
货号:c1116-1gm | 规格:1 g | 价格:¥0.00 | 品牌:ProteoChem
SPDP Crosslinker/SPDP交联剂是一种可切割,不溶于水,氨基和硫醇(巯基)反应性异双功能交联剂,CAS号68181-17-9,间隔长度6.8 Å。

SPDP crosslinker (N-Succinimidyl 3-[2-pyridyldithio]-propionate) is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The SPDP crosslinking reagent crosslinks protein or peptides via reactive moites consisting of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines, as found in lysine side chains or the N-terminus of proteins and peptides; on the other end of the SPDP crosslinking molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond which can be reduced with TCEP-HCl or DTT.

ProteoChem also offers a "long chain" version of the SPDP protein crosslinker. LC-SPDP crosslinker has a 15.7 angstrom spacer arm, compared to the shorter 6.8 angstrom spacer arm version of the SPDP protein crosslinker. Often, due to steric hindrances, it is desirable to empirically test which of the two versions will work best in your specific application.

分子量: 312.36

间隔长度: 6.8 Å

CAS号: 68181-17-9

别名: 3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester; SPDP Cross-Linker

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