产品特性
Anti Thymidine Glycol(TG) monoclonal antibody
Subclass: 小鼠IgG1 (kappa), clone 2E8
Specificity: Specific for DNA fragment containing thymidine glycol, and thymidine glycol polymer.
Suitable for immunohistocheistry.
| 规格 | 价格 |
|---|---|
| 100 µg | ￥咨询 |
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详细介绍
产品名称：Thymidine Glycol(TG)抗体
别名：Anti thymidineglycol monoclonal antibody；Anti thymidineglycol antibody; Anti TG monoclonal antibody; Anti TG antibody；Anti Thymidine glycol antibody; 抗Thymidineglycol抗体；抗Thymidine Glycol抗体; 抗TG抗体；胸腺嘧啶乙二醇抗体; 胸苷二醇抗体; 抗胸苷乙二醇抗体
应用：Immunohistochemistry (antibody conc. 5 - 10 µg/mL)
克隆：2E8
储存条件：Less than -20°C
[对DNA氧化具有特异性]
胸苷乙二醇（Thymidineglycol, TG）是DNA的主要氧化产物之一。胸苷（T）可因辐射及能量代谢等氧化应激作用而受损。目前认为TG的形成存在两种途径：1）DNA中的脱氧胸苷经羟基自由基直接氧化形成TG；2）通过中性粒细胞髓过氧化物酶产生的次氯酸（HOCl）生成中间产物胸苷氯醇，进而转化为TG。
需特别说明的是，胸苷乙二醇仅来源于DNA，而非RNA，因此TG是DNA损伤的特异性氧化应激标志物。
[与8-OHdG的比较]
8-hydroxy-2'-deoxyguanosine (8-OHdG) is one of the well-known DNA oxidation products. In an lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained in 24 hours after LPS treatment. TG can be detected in 6 hours, and remain at least for 72 hours. Anti TG monoclonal antibody (clone 2E8) has been established by Dr. Toshihiko Osawa (Nagoya Univ.). Poly dT (50 mer) has been oxidised by OsO4 and injected to Balb/c mouse as immunogen. This antibody can react with thymidineglycol in DNA or TG polymer, and suitable for immunohistochemistry.
抗原： Thymidineglycol polymer.
性状：Lyophilized power. Reconstitute by 1000 µL of distilled water. 100 µg/mL of IgG.
亚类： Mouse IgG1 (kappa)
特异性：Specific for DNA fragment containing thymidine glycol, and thymidine glycol polymer.
Cross reactivity have been tested to following analogues: oxidized deoxycytidine polymer, oxidized deoxyguanosine polymer and oxidized deoxyadenosine polymer. Not react with free thymidineglycol.
[注意事项]：我们的抗胸苷乙二醇（Thymidineglycol）抗体仅用于研究用途。不可用于诊断、医疗或其他用途。
[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.
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胸苷乙二醇（Thymidineglycol, TG）是DNA的主要氧化产物之一。胸苷（T）可因辐射及能量代谢等氧化应激作用而受损。目前认为TG的形成存在两种途径：1）DNA中的脱氧胸苷经羟基自由基直接氧化形成TG；2）通过中性粒细胞髓过氧化物酶产生的次氯酸（HOCl）生成中间产物胸苷氯醇，进而转化为TG。
需特别说明的是，胸苷乙二醇仅来源于DNA，而非RNA，因此TG是DNA损伤的特异性氧化应激标志物。
[与8-OHdG的比较]
8-hydroxy-2'-deoxyguanosine (8-OHdG) is one of the well-known DNA oxidation products. In an lipopolysaccharide (LPS)-treated mouse liver, 8-OHdG can be stained in 24 hours after LPS treatment. TG can be detected in 6 hours, and remain at least for 72 hours. Anti TG monoclonal antibody (clone 2E8) has been established by Dr. Toshihiko Osawa (Nagoya Univ.). Poly dT (50 mer) has been oxidised by OsO4 and injected to Balb/c mouse as immunogen. This antibody can react with thymidineglycol in DNA or TG polymer, and suitable for immunohistochemistry.
抗原： Thymidineglycol polymer.
性状：Lyophilized power. Reconstitute by 1000 µL of distilled water. 100 µg/mL of IgG.
亚类： Mouse IgG1 (kappa)
特异性：Specific for DNA fragment containing thymidine glycol, and thymidine glycol polymer.
Cross reactivity have been tested to following analogues: oxidized deoxycytidine polymer, oxidized deoxyguanosine polymer and oxidized deoxyadenosine polymer. Not react with free thymidineglycol.
[注意事项]：我们的抗胸苷乙二醇（Thymidineglycol）抗体仅用于研究用途。不可用于诊断、医疗或其他用途。
[NOTICE]: Our products are for RESEARCH USE ONLY. Not for diagnostic, medical or other use.
