Murine Anti-GPIba抗体(GMA-340)
货号：GMA-340
品牌：Greenmoab
产品特性
Specificity：Shedding cleavage site of GPIba
Immunogen：Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.
Application：ELISA and Immunoblotting
| 规格 | 价格 |
|---|---|
| 0.1 mg | ￥咨询 |
| 0.5 mg | ￥咨询 |
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产品订购：sales@biopcr.com
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服务热线：400-860-6200
详细介绍
产品名称：Murine Anti-GPIba抗体(GMA-340)
别名：Murine Anti-GPIba Antibody；Murine Anti-GPIba Monoclonal Antibody；Platelet membrane glycoprotein Ib Antibody；GPIb-Alpha Antibody；Mouse Anti-GPIba Antibody；GPIb alpha Antibody；GP1BA Antibody；CD42b抗体；GPIb alpha抗体；GP1BA抗体；GPIb-Alpha抗体；Platelet membrane glycoprotein Ib抗体；小鼠抗血小板膜糖蛋白Iba抗体；Murine Anti-GPIba单克隆抗体；小鼠抗GPIba抗体；Murine Anti-GPIba抗体；小鼠抗血小板膜糖蛋白Ibα抗体
克隆号（Clone）：GMA-340
背景介绍（Background）：
Platelet membrane glycoprotein Ib (GPIba) is comprised of an alpha and beta subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465. Liang et al. have shown that the murine monoclonal antibody designated 5G6 (GMA-340) binds the ADAM17 cleavage site and blocks glycocalicin release.
种属反应性（Species Reactivity）: Human
来源（Source）： Murine
特异性（Specificity）： Shedding cleavage site of GPIba
免疫原（Immunogen）： Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.
亚型（Isotype）： IgG1
应用（Application）：
ELISA： Binds immobilized human platelet GPIba and synthetic peptide
Immunoblotting： Binds under reduced and non-reduced conditions
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
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背景介绍（Background）：
Platelet membrane glycoprotein Ib (GPIba) is comprised of an alpha and beta subunit linked by disulfide bonds. GPIba (also known as CD42b) is a 135 kDa membrane protein subunit that binds a variety of adhesive and procoagulant ligands, including von Willebrand factor. Cleavage of GPIba by the “sheddase” ADAM17 releases the ectodomain glycocalicin into plasma. ADAM17 cleaves GPIba at Gly464-Val465. Liang et al. have shown that the murine monoclonal antibody designated 5G6 (GMA-340) binds the ADAM17 cleavage site and blocks glycocalicin release.
种属反应性（Species Reactivity）: Human
来源（Source）： Murine
特异性（Specificity）： Shedding cleavage site of GPIba
免疫原（Immunogen）： Human GPIba peptide (Ac-ELDQPPKLRG VLQGHLESSRNDPFC- amide) conjugated to ovalbumin.
亚型（Isotype）： IgG1
应用（Application）：
ELISA： Binds immobilized human platelet GPIba and synthetic peptide
Immunoblotting： Binds under reduced and non-reduced conditions
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
