Murine Anti-Factor VIII抗体(GMA-8014)
货号：GMA-8014
品牌：Greenmoab
产品特性
Specificity：C2 Domain
Immunogen：B-domain deleted recombinant Human Factor VIII
Application：ELISA and Inhibition
| 规格 | 价格 |
|---|---|
| 0.1 mg | ￥咨询 |
| 0.5 mg | ￥咨询 |
产品咨询：info@biopcr.com
产品订购：sales@biopcr.com
技术支持：tech@biopcr.com
服务热线：400-860-6200
详细介绍
产品名称：Murine Anti-Factor VIII抗体(GMA-8014)
别名：Murine Anti-Factor VIII Antibody；Murine Anti-Factor VIII Monoclonal Antibody；Murine Anti-Factor VIII单克隆抗体；Factor VIII抗体；Murine Anti-Factor VIII抗体；小鼠抗凝血因子VIII抗体；Mouse Anti-Factor VIII Antibody；F8抗体
克隆号（Clone）：GMA-8014
背景介绍（Background）：
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor (vWF). Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8014 (also known as 3G6 or 3G6.1B)1 recognizes the C2 domain of FVIII. The antibody strongly inhibits FVIII activation and is unaffected by the presence of vWF or phospholipid membranes.1 GMA-8014 detects FVIII C2 domain by surface plasmon resonance,2,3 and is suitable for ELISA and bio-layer interferometry pairing experiments.
种属反应性（Species Reactivity）: Human
来源（Source）： Murine
特异性（Specificity）： C2 Domain
免疫原（Immunogen）： B-domain deleted recombinant Human Factor VIII
亚型（Isotype）： IgG2b
应用（Application）：
ELISA： Binds the C2 domain of recombinant human factor VIII in solid-phase ELISA..
Immunoblotting： Does not blot.
Inhibition： Strongly inhibitory in aPTT clotting assay.
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
返回列表
背景介绍（Background）：
Factor VIII (FVIII) is a heterodimer consisting of a heavy chain (ranging in mass from 90 to 200 kDa) bound via metal ions to a light chain (80 kDa). In plasma, FVIII circulates in an inactive form bound to von Willebrand factor (vWF). Following activation by factor Xa or thrombin, factor VIIIa can function as cofactor for the enzyme factor IXa in the activation of factor X in the presence of phospholipid and Ca2+. Absent or defective FVIII is the cause of the X-linked recessive bleeding disorder hemophilia A. GMA-8014 (also known as 3G6 or 3G6.1B)1 recognizes the C2 domain of FVIII. The antibody strongly inhibits FVIII activation and is unaffected by the presence of vWF or phospholipid membranes.1 GMA-8014 detects FVIII C2 domain by surface plasmon resonance,2,3 and is suitable for ELISA and bio-layer interferometry pairing experiments.
种属反应性（Species Reactivity）: Human
来源（Source）： Murine
特异性（Specificity）： C2 Domain
免疫原（Immunogen）： B-domain deleted recombinant Human Factor VIII
亚型（Isotype）： IgG2b
应用（Application）：
ELISA： Binds the C2 domain of recombinant human factor VIII in solid-phase ELISA..
Immunoblotting： Does not blot.
Inhibition： Strongly inhibitory in aPTT clotting assay.
储存（Storage）：Aliquot and store at -20℃ for prolonged periods. Avoid freeze-thaw cycles. Alternatively, add 0.02% (w/v) sodium azide and store at 4℃.
