ICG-DOTA琥珀酰亚胺酯
货号：257
品牌：AAT Bioquest
产品特性
多模态成像：结合近红外荧光活体成像和核成像（PET/SPECT），实现全面的分子可视化。
高亲和力放射性金属螯合：DOTA部分与用于PET（⁶⁴Cu）、SPECT（¹¹¹In）和放射治疗（¹⁷⁷Lu、⁹⁰Y）的同位素形成稳定的复合物。
高效生物偶联：琥珀酰亚胺酯（SE）能与伯胺形成稳定的酰胺键，同时保持生物分子功能。
诊疗一体化多功能性：支持生物医学应用中的双模态成像、精准诊断和靶向放射治疗。
高稳定性：保持放射化学和光稳定性，确保在分子成像和药物递送中的可靠性能。
| 规格 | 价格 |
|---|---|
| 1 mg | ￥咨询 |
产品咨询：info@biopcr.com
产品订购：sales@biopcr.com
技术支持：tech@biopcr.com
服务热线：400-860-6200
详细介绍
产品名称：ICG-DOTA琥珀酰亚胺酯
别名：ICG-DOTA Succinimidyl Ester
储存条件：冷冻（< -15 °C）；避光保存
ICG-DOTA Succinimidyl Ester is a dual-modal imaging probe combining near-infrared indocyanine green fluorophore with DOTA chelator for radiolabeling, enabling both optical and PET/SPECT imaging in a single conjugate.
Multimodal Imaging: Combines NIR fluorescence in vivo imaging and nuclear imaging (PET/SPECT) for comprehensive molecular visualization
High-Affinity Radiometal Chelation: DOTA moiety forms stable complexes with isotopes used in PET (⁶⁴Cu), SPECT (¹¹¹In), and radiotherapy (¹⁷⁷Lu, ⁹⁰Y)
Efficient Bioconjugation: Succinimidyl ester (SE) enables stable amide bond formation with primary amines, preserving biomolecular function
Theranostic Versatility: Supports dual-modal imaging, precision diagnostics, and targeted radiotherapeutics in biomedical applications
High Stability: Maintains radiochemical and photostability for reliable performance in molecular imaging and drug delivery
ICG-DOTA Succinimidyl Ester is a dual-functional imaging probe that combines near-infrared (NIR) in vivo imaging with high-affinity radiometal chelation, enabling both optical and nuclear imaging for multimodal applications. This conjugate leverages the deep-tissue imaging capabilities of indocyanine green (ICG) and the versatile chelation properties of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), making it ideal for fluorescence-guided imaging, positron emission tomography (PET), single-photon emission computed tomography (SPECT), and targeted radiotherapeutic applications.
The succinimidyl ester (SE) functional group facilitates efficient and selective conjugation to primary amines on biomolecules, forming stable amide linkages under physiological conditions while preserving biomolecular activity. The NIR fluorescence of ICG (excitation ~780 nm, emission ~810 nm) enables deep-tissue penetration with minimal background autofluorescence, making it highly suitable for in vivo fluorescence imaging. Simultaneously, the DOTA moiety chelates a wide range of radiometals, forming thermodynamically stable and kinetically inert complexes with isotopes commonly used in molecular imaging and targeted radiotherapy. These include positron-emitting isotopes (e.g., ⁶⁴Cu for PET), gamma-emitting isotopes (e.g., ¹¹¹In for SPECT), and therapeutic radionuclides (e.g., ¹⁷⁷Lu, ⁹⁰Y) for targeted radiotherapy.
By integrating high-resolution fluorescence imaging with radiolabeling capabilities, ICG-DOTA Succinimidyl Ester provides a versatile platform for developing precision imaging agents, theranostic probes, and multimodal tracers. Its optimized bioconjugation chemistry, strong radiochemical stability, and NIR fluorescence properties make it a powerful tool for biomedical research and translational applications in oncology, molecular diagnostics, and targeted drug delivery.
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Multimodal Imaging: Combines NIR fluorescence in vivo imaging and nuclear imaging (PET/SPECT) for comprehensive molecular visualization
High-Affinity Radiometal Chelation: DOTA moiety forms stable complexes with isotopes used in PET (⁶⁴Cu), SPECT (¹¹¹In), and radiotherapy (¹⁷⁷Lu, ⁹⁰Y)
Efficient Bioconjugation: Succinimidyl ester (SE) enables stable amide bond formation with primary amines, preserving biomolecular function
Theranostic Versatility: Supports dual-modal imaging, precision diagnostics, and targeted radiotherapeutics in biomedical applications
High Stability: Maintains radiochemical and photostability for reliable performance in molecular imaging and drug delivery
ICG-DOTA Succinimidyl Ester is a dual-functional imaging probe that combines near-infrared (NIR) in vivo imaging with high-affinity radiometal chelation, enabling both optical and nuclear imaging for multimodal applications. This conjugate leverages the deep-tissue imaging capabilities of indocyanine green (ICG) and the versatile chelation properties of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), making it ideal for fluorescence-guided imaging, positron emission tomography (PET), single-photon emission computed tomography (SPECT), and targeted radiotherapeutic applications.
The succinimidyl ester (SE) functional group facilitates efficient and selective conjugation to primary amines on biomolecules, forming stable amide linkages under physiological conditions while preserving biomolecular activity. The NIR fluorescence of ICG (excitation ~780 nm, emission ~810 nm) enables deep-tissue penetration with minimal background autofluorescence, making it highly suitable for in vivo fluorescence imaging. Simultaneously, the DOTA moiety chelates a wide range of radiometals, forming thermodynamically stable and kinetically inert complexes with isotopes commonly used in molecular imaging and targeted radiotherapy. These include positron-emitting isotopes (e.g., ⁶⁴Cu for PET), gamma-emitting isotopes (e.g., ¹¹¹In for SPECT), and therapeutic radionuclides (e.g., ¹⁷⁷Lu, ⁹⁰Y) for targeted radiotherapy.
By integrating high-resolution fluorescence imaging with radiolabeling capabilities, ICG-DOTA Succinimidyl Ester provides a versatile platform for developing precision imaging agents, theranostic probes, and multimodal tracers. Its optimized bioconjugation chemistry, strong radiochemical stability, and NIR fluorescence properties make it a powerful tool for biomedical research and translational applications in oncology, molecular diagnostics, and targeted drug delivery.
