Atibuclimab生物类似药-研究级
货号：ICH5016-10mg
品牌：ichorbio
产品特性
英文名称: Atibuclimab Biosimilar - Research Grade
内毒素水平≤ 1.0 EU/mg
纯度：>95% by SDS-PAGE
应用: Functional Assays.
| 规格 | 价格 |
|---|---|
| 10mg | ￥咨询 |
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详细介绍
产品名称：Atibuclimab生物类似药-研究级
别名：Atibuclimab Biosimilar-Research Grade
应用：Functional Assays
亚型：Human IgG4
浓度：5mg/ml
反应性：Human
特异性：Detects human CD14. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Atibuclimab.
存储溶液：Sterile, preservative-free, solution in PBS. BSA and Azide free.
储存条件：This biosimilar is stable when stored at 2-8°C. For longer term storage (> 3 months) it is recommended to store this antibody at -20°C or -70°C.
推荐同型对照（Isotype Control）：Bulk Human IgG4 Isotype Control (IB4) [ICH2257]
推荐缓冲液（Buffer）：体内抗体缓冲液pH7.4
靶点（Target）: CD14
UniProt：P08571
纯化方法（Purification method）： This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
背景资料（Background）：RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.
内毒素（Endotoxin）：≤ 1.0 EU/mg as determined by the LAL method
纯度（Purity）：>95% by SDS-PAGE
应用说明（Application Notes）：This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
产品使用（Use）：Products are for research use only. Not for use in diagnostic or therapeutic procedures.
运输条件：Blue ice
返回列表
推荐缓冲液（Buffer）：体内抗体缓冲液pH7.4
靶点（Target）: CD14
UniProt：P08571
纯化方法（Purification method）： This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
背景资料（Background）：RUO atibuclimab is a chimeric CD14 antibody investigated for the treatment of patients with severe sepsis. It acts as a pattern recognition receptor for bacterial cell wall components in gram-positive and negative bacteria. CD14 antibody action stimulates a pro-inflammatory cytokine cascade often associated with inflammation in sepsis. Atibuclimab neutralization of this antibody results in the inhibition of TNF-a, IL-6 and IL-10, dampening systemic inflammatory responses. Atibuclimab also delays the release of sTNFR(1) and IL-1ra.
内毒素（Endotoxin）：≤ 1.0 EU/mg as determined by the LAL method
纯度（Purity）：>95% by SDS-PAGE
应用说明（Application Notes）：This biosimilar is for research use only (RUO): it is not for diagnostic or therapeutic procedures and cannot be purchased by patients.
产品使用（Use）：Products are for research use only. Not for use in diagnostic or therapeutic procedures.
运输条件：Blue ice
